Lung cancer risk falls dramatically if you quit smoking

While lung cancer risk falls five years after quitting, it remains substantially higher than non-smokers

Just because you stopped smoking years ago doesn’t mean you’re out of the woods when it comes to developing lung cancer.

That’s the “bad” news. The good news is your risk of lung cancer drops substantially within five years of quitting.

These are the main findings of a new analysis of the landmark Framingham Heart Study by researchers at Vanderbilt University Medical Center published May 16 by the Journal of the National Cancer Institute.

“If you smoke, now is a great time to quit,” said first author Hilary Tindle, MD, MPH, the William Anderson Spickard Jr., MD Professor of Medicine at the Vanderbilt University School of Medicine and director of the Vanderbilt Center for Tobacco, Addiction and Lifestyle.

“The fact that lung cancer risk drops relatively quickly after quitting smoking, compared to continuing smoking, gives new motivation,” she said.

In India, lung cancer constitutes 6.9 per cent of all new cancer cases and 9.3 per cent of all cancer related deaths in both sexes, it is the commonest cancer and cause of cancer related mortality in men, with the highest reported incidences from Mizoram in both males and females. A 2015 article in the Indian Journal of Medical Research said that time trends of lung cancer show a significant rise in Delhi, Chennai and Bengaluru in both sexes.

Five years after quitting, the risk of developing lung cancer in former heavy smokers dropped by 39 percent compared to current smokers…Yet even 25 years after quitting, their lung-cancer risk remained over threefold higher

Tindle and her colleagues examined the health records of residents of Framingham, Massachusetts, who have been followed for decades by the Framingham Heart Study. The study, which is supported by the National Heart, Lung, and Blood Institute, helped establish high blood pressure and high cholesterol as key risk factors for cardiovascular disease. But it also tracked cancer outcomes.

The current study looked at 8,907 participants who had been followed for 25 to 34 years. During this period, 284 lung cancers were diagnosed, nearly 93 percent of which occurred among heavy smokers, those who had smoked at least a pack of cigarettes a day for 21 years or more.

Five years after quitting, the risk of developing lung cancer in former heavy smokers dropped by 39 percent compared to current smokers, and continued to fall as time went on. Yet even 25 years after quitting, their lung-cancer risk remained over threefold higher compared to people who had never smoked.

The Framingham study is unique because it asked people about their smoking every two to four years, and could account for increases or decreases in smoking over time. Further study is warranted to determine whether extending the cut-off point for mandated screening would be cost-effective and save lives, the researchers concluded.

“While the importance of smoking cessation cannot be overstated, former heavy smokers need to realize that the risk of lung cancer remains elevated for decades after they smoke their last cigarette, underscoring the importance of lung cancer screening,” said senior author Matthew Freiberg, MD, MSc, professor of Medicine.