A natural product has been discovered that reduced the level of damaged cells in the body, caused by ageing
Researchers at the University of Minnesota Medical School have shown that treatment of aged mice with the natural product Fisetin has significant positive effects on health and lifespan. Fisetin is found in many fruits and vegetables.
As people age, they accumulate damaged cells. When the cells get to a certain level of damage, they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells.
A younger person’s immune system is healthy and is able to clear the damaged cells. But as people age, they aren’t cleared as effectively. Thus they begin to accumulate, cause low level inflammation and release enzymes that can degrade the tissue.
Previous research published earlier this year in Nature Medicine, showed that damaged cells, termed senescent cells can cause physical dysfunction and decreased survival even in young mice, while senolytics can enhance remaining health and lifespan in old mice.
This is the first demonstration that shows the effects of the drug on specific subsets of these damaged cells within a given tissue
Researchers found a natural product, called Fisetin, that has senotherapeutic activity in mice and in human tissues. It reduces the level of these damaged cells in the body. They found treating mice towards the end of life with this compound had improvement in both health and lifespan. The paper, “Fisetin is a senotherapeutic that extends health and lifespan,” was recently published in EBioMedicine.
“These results suggest that we can extend the period of health, termed healthspan, even towards the end of life,” said study author Paul D. Robbins. “But there are still many questions to address, including the right dosage, for example.” The team used mass cytometry, or CyTOF, technology for this research.
“In addition to showing that the drug works, this is the first demonstration that shows the effects of the drug on specific subsets of these damaged cells within a given tissue,” Robbins added.
These characteristics suggest the practicality of Fisetin to undergo human clinical trials.
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