Tuesday, November 5, 2024
HomeDoc's CornerNew blood test could avoid 40% prostate biopsies

New blood test could avoid 40% prostate biopsies

A new blood test called IsoPSA may reduce the need for prostate biopsies in more than 40% cases

A new study has proved the accuracy of IsoPSA – a new blood test – in predicting overall risk of prostate cancer than standard prostate-specific antigen (PSA) test. The study was presented  at the 13th Annual Meeting of the American Urological Association (AUA) on May 18 in San Francisco.

Results showed that more than 40 percent of biopsies could have been avoided in both the preliminary study (45.1 percent) and validation study (47 percent) for diagnosis of prostate cancer. IsoPSA use may substantially reduce the need for biopsy, and may thus lower the likelihood of overdetection and overtreatment of nonlethal prostate cancer.

The PSA test is used routinely in many parts of the world for detection of prostate cancer but PSA levels are affected by many factors other than prostate cancer and that leads to a high number of false positives for prostate cancer.

A study published in the New England Journal of Medicine in 2009 stated, “The rate of overdiagnosis of prostate cancer (defined as the diagnosis in men who would not have clinical symptoms during their lifetime) has been estimated to be as high as 50% in the screening group.”

Falsely raised PSA levels are seen in cases of an enlarged prostate or infected prostate, a recent rectal exam, an urinary tract infection and even a lot of sex can falsely increase the PSA reading. The test cannot indicate the difference between a slow-growing cancer and an aggressive cancer.

The study, Prospective Validation of the IsoPSA Assay for Detection of High Grade Prostate Cancer was  led by Eric Klein, M.D. of Cleveland Clinic, who conducted a multicenter confirmation trial and evaluated data including cutoff parameters derived from a preliminary study. The detection of cancer by biopsy was the endpoint.

In Indian males prostate cancer is the second commonest cancer as per data from the Indian Council of Medical Research. The incidence rate in India is 9-10/100000 population

The study was a follow-up to earlier studies which showed that IsoPSA, a protein biomarker, may be an effective test for differentiating between high-grade prostate cancer (Gleason≥7) and low-grade/benign disease (Gleason=6). A Gleason score is derived from 2 examinations of the biopsy — the first evaluating the architectural features of the prostate gland, and the second looking at the level of abnormality of the cell nucleoli. The combined total is the Gleason score and it is used for histopathological staging of prostate cancer.

Prostate cancer is the second most common cause of cancer and the sixth in terms of cancer mortality among men the world over. Experts predict that the number of cases will double by 2020. In Indian males prostate cancer is the second commonest cancer as per data from the Indian Council of Medical Research. The incidence rate in India is 9-10/100000 population which though is lower than USA and Europe.

“To be clinically useful, a biomarker must be both tissue-specific and cancer-specific. While PSA is prostate-specific, it is not specific for prostate cancer, leading to diagnostic inaccuracy and too many unneeded biopsies,” said Dr. Klein, chair of Cleveland Clinic’s Glickman Urological & Kidney Institute. “IsoPSA fulfills both the tissue- and cancer-specificity needed for a useful biomarker, and this validation study shows that it can more accurately detect high-grade cancer and reduce the rate of unneeded biopsies in patients at low risk of this disease.”

MediBulletin Bureau
MediBulletin Bureau
A team of experienced and committed journalists. Working under guidance of Dr. O. P. Choudhury. You can reach us at: bureau@medibulletin.com
Latest

75 COMMENTS

  1. Cool one! Interesting information over here. It’s pretty worth enough for me. In my opinion, if all website owners and bloggers made good content as you did, the net will be much more useful than ever before.| I could not resist commenting. I have spent some hours looking for such article. I will also share it with some friends interested in it. I’ve just bookmarked this web. Right now with the job done, I’ll find some live gay cams. Thank you!!Greetings from Los Angeles!

  2. It’s a pity you don’t have a donate button! I’d definitely donate to this brilliant blog! I guess for now i’ll settle for book-marking and adding your RSS feed to my Google account. I look forward to fresh updates and will talk about this website with my Facebook group. Chat soon!

  3. Cool info! Interesting info over this website. It’s pretty worth enough for me. In my view, if all web owners and bloggers made good content as you did, the web will be much more useful than ever before. I couldn’t refrain from commenting. I have spent 3 hours looking for such informations. I will also share it with some friends interested in it. I’ve just bookmarked this website. Right now with the job done, I going to find some model sexy men cams. Thank you!! Greetings from Orlando!

  4. I’m extremely impressed along with your writing abilities and also with the format on your weblog.

    Is this a paid theme or did you modify it yourself?

    Either way keep up the excellent quality writing, it is
    rare to look a great weblog like this one today..

  5. Great beat ! I wouyld like to apprentice while yoou
    akend your web site, how can i subscribe for a blog web site?
    The account helped me a appropriate deal. I had been tiny bit acquainted of this
    our broadcast offered vibrant clear concept

  6. Does your website have a contact page? I’m having a tough time locating it but, I’d like to shoot you an email. I’ve got some creative ideas for your blog you might be interested in hearing. Either way, great blog and I look forward to seeing it expand over time.

  7. Thanks for another informative web site. Where else may I am getting that type of information written in such an ideal means? I have a undertaking that I’m just now running on, and I’ve been at the glance out for such info.

  8. I have been exploring for a bit for any high quality articles or
    blog posts in this sor off holuse . Exploring in Yahoo I eventually stumbled upon this web site.

    Studying this info So i am glad to express tjat I have an incredibly
    excellent uncanny feeling I discovered just what I needed. I most no doubt will make sure too do not forget this web sie and give it a glanbce on a relentless basis.

  9. Excellent pieces. Keep writing such kind of info on your
    blog. Im really impressed by it.
    Hello there, You’ve doe a fantastic job. I will certainly digg it and individually suggest to my friends.
    I am sure they will be beefited from this web site.

  10. Hey there I am so excited I found your webpage, I really found you by error, while I was researching on Digg for something else, Nonetheless I am here now and would just like to say thank you for a incredible post and a all round exciting blog (I also love the theme/design), I don’t have time to read it all at the moment but I have saved it and also added your RSS feeds, so when I have time I will be back to read a great deal more, Please do keep up the awesome b.

  11. Write more, thats all I have to say. Literally, it seems as
    though you relied on the video to make your point.
    You clearly know what youre talking about, why waste your intelligence on just posting videos to
    your site when you could be giving us something enlightening to
    read?

  12. You’re so cool! I don’t believe I’ve read something like that before.
    So good to discover somebody with original thoughts on this subject matter.
    Really.. thank you for starting this up. This site is one thing
    that is required on the internet, someone with a bit
    of originality!

  13. Very nice post. I just stumbled upon your weblog and wanted to saay that I’ve truly enjoyed browsing your blog posts.
    After alll I’ll be subscribing to your feed and I hope you write
    again very soon!

  14. Write more, thats all I have to say. Literally,
    it seems as though you relied on the video to
    make your point. You clearly know what youre talking about,
    why throw away your intelligence on just posting videos to your
    weblog when youu culd be giving us something enlightening to read?

  15. Very great post. I simply stumbled upon your weblog and wished to mention that I’ve truly
    loved browsing your weblog posts. After all I’ll be subscribing
    on your feed and I’m hoping you write again very soon!

  16. My pal advisable I’d probably by way of example this blog. He was solely perfect kumpulan youtube terbaru. This specific publish genuinely. made our day. It is easy to certainly not think about how a bunch. moment I’d put in due to this info! Many thanks!

  17. Today, I went to the beachfront with my children. I
    found a sea shell and gave it too my 4 year old daughter and said
    “You can hear the ocean if you put this to your ear.”She put the shell to her ear
    and screamed. There waas a hermit crab inside and it pinched hher
    ear. She never wants to go back! LoL I know this is totally off topic
    but I hadd to tell someone!

  18. Heya i am for the first time here. I found this board and I find It
    truly useful & it helped me out much. I hope to
    give something back and aid others like you aided me.

  19. Hey There. I discovered yoir blog the usage of msn.
    That is a really neawtly written article. I’ll make sure to bookmark it andd return to reaad extra of your
    helpful info. Thanks for the post. I’ll certainly comeback.

  20. Whoa, incredible web site structure! The length of time have you been blogging and site-building pertaining to? you earn blogging and site-building start looking koleksi youtube terfavorit easy. The total view of one’s web site is astounding, not to the content!

  21. Cool blog! Is your theme custom made or did you download it from somewhere? A theme like yours with a few simple tweeks would really make my blog jump out. Please let me know where you got your design. Thanks

  22. An interesting discussion is worth comment. I blieve that you ought to publish more on this issue,
    it may not be a taboo subject but typically folks don’t discuss such subjects.

    To the next! Best wishes!!

  23. Howdy, i read your blog from time to time and i own a similar one and i wwas just wondering if you get a
    lot of spam responses? If so how do you reduce it, any
    plugin or anything you can suggest? I gget so much lately it’s driving me crazy sso any support is very much appreciated.

  24. Hmm it seems liike your blog ate my first comment (it was extremely long) so I guess
    I’ll just sum it up what I wrote and say, I’m thoroughly enjoying your blog.
    I as well am an spiring blog blogger but I’mstill new to everything.
    Do youu have aany helpful hints for first-time blog writers?
    I’d certainly appreciate it.

  25. Greetings! I know this is somewhat off topic but I was wondering which blog platform are you using for this site? I’m getting fed up of WordPress because I’ve had issues with hackers and I’m looking at alternatives for another platform. I would be awesome if you could point me in the direction of a good platform.

  26. After I originallly left a comment I seem to havce clicked on the -Notify me wen neew comments aare added- checkbox
    and now each time a comment is added I receive four emails wth the same comment.
    Perhaps there iss a way you are able to remove me from that service?
    Cheers!

  27. Unquestionably imagine that which you said. Your favorite justification seemed
    to be att the internet the simplest thing to take into accout of.
    I saay to you, I definitely get irked whilst other people think about worries that they just doo not recognize
    about. You managed to hit the nail upon the top and outlined
    out the whple thing with no need side effect , folks can take a signal.

    Will likely be again tto get more. Thanks

  28. Good one! Interesting article over this web. It is pretty worth enough for me. Personally, if all website owners and bloggers made good content as you did, the internet will be a lot more useful than ever before.| I couldn’t resist commenting. I have spent some time searching for such article. I will also share it with a couple of friends interested in it. I have just bookmarked this website. Finished with the job done, I’ll enjoy some World cup Webcams. Thanks!! Regards from Russia 2018!

  29. Good! Interesting info over this web. It’s pretty worth enough for me. In my opinion, if all website owners and bloggers made good content as you did, the net will be much more useful than ever before.| I couldn’t refrain from commenting. I have spent 1 hour searching for such tips. I’ll also share it with a couple of friends interested in it. I’ve just bookmarked this website. Done with the task done, I going to visit some Russia 2018 Webcams. Gracias!!! Regards from Mundial 2018!

  30. Exceⅼlent post. I was cһeϲking constantly this blog and I am
    impressed! Ꮩery helpful іnformation specifically the last part 🙂 I care for sᥙcһ iinformation a
    lot. I was looking for tnis certain info for a very long tіme.
    Thank yyou and beѕt of luck.

  31. It’s a shame you don’t have a donate button! I’d without
    a doubt donate to this outstanding blog! I guess for now i’ll settle for bookmarking and adding your RSS feed to my Google account.
    I look forward to fresh updates and will share this site with my Facebook group.
    Chat soon!

Comments are closed.

- Advertisment -
NEWS