Toxic chemicals like copper, lead, arsenic harm the heart

heart attack
heart attack

New research shows toxic metal contaminants in food and water affects cardiovascular health

Even low doses of toxic chemicals in the environment pose a significant risk to cardiovascular health.

In a report published in The BMJ, researchers led by University of Cambridge have challenged the omission of toxic metal contamination from the recent World Health Organization report on non-communicable diseases (NCDs).

In recent decades, exposures to environmental toxic metals such as arsenic, copper, lead, cadmium and mercury, have become a global public health concern. Although often naturally occurring, these contaminants have made their way into water supplies and, via irrigation, into the food chain.

For example, in Bangladesh and in some parts of India, deep wells were introduced in the Ganges Delta to draw water clear of bacterial and viral pathogens, but this inadvertently led to exposure to toxic metals.

For example, in Bangladesh and in some parts of India, deep wells were introduced in the Ganges Delta but this inadvertently led to exposure to toxic metals

Concern has often focused on the toxicity or carcinogenic properties of the metals, particularly at high doses. However, there is increasing evidence to suggest that heavy metals may have other adverse effects on health – including cardiovascular disease such as heart disease and stroke – even at lower levels of exposure, which might be prevalent in many parts of the world, including the UK and the US.

To interpret the available evidence, a team led by researchers at Cambridge’s Department of Public Health and Primary Care carried out a systematic review and meta-analysis of published studies covering 350,000 unique participants from 37 countries.

The results of the study showed that exposure to arsenic, lead, cadmium and copper – but not mercury – was associated with an increased risk of coronary heart disease and cardiovascular disease.

“It’s clear from our analysis that there’s a possible link between exposure to heavy metals or metalloids and risk of conditions such as heart disease, even at low doses – and the greater the exposure, the greater the risk,” says Dr Rajiv Chowdhury, the study’s first author. “While people shouldn’t be overly worried about any immediate health risk, it should send a message to policymakers that we need to take action to reduce people’s exposure.”

Worldwide, those with greatest exposure of arsenic, lead, cadmium and copper were around 30% to 80% more likely to develop cardiovascular disease than those at lowest exposure.

The report is important, say the researchers, because it highlights the need to tackle this environmental and public health problem, one which disproportionately affects people in low and middle income countries. Interventions need not be costly, they stress; for example, cheap, scalable technologies (e.g. environmentally-friendly water filters) or behavioural interventions (e.g. rinsing practices of rice and vegetables prior to cooking) are currently being tested to reduce exposures at the household level.

Additionally, in a letter published at the end of June, Dr Chowdhury and colleagues expressed their disappointment that the earlier WHO report by the Independent High-Level Commission on non-communicable diseases published in June did not include exposure to heavy metals as a key contributing factor.

Writing in the Lancet, the authors said: “Unfortunately, this globally important report had a major omission: recognising the detrimental role of environmental risk factors, beyond the conventional behavioural factors (tobacco and alcohol use, physical inactivity, and unhealthy diet), in enhancing global NCD burden and health inequality.”