India has a high burden of people living with dyslipidemia
Less than 40 percent of people with severe elevations in cholesterol are being prescribed appropriate drug treatment, according to a study reported in the American Heart Association’s journal Circulation.
Data from the 1999-2014 National Health and Nutrition Examination Survey was used to estimate prevalence rates of self-reported screening, awareness and statin therapy among U.S. adults age 20 and older with severely elevated LDL or “bad cholesterol” levels of 190 mg/dL or higher. In addition, they considered a subgroup of patients with familial hypercholesterolemia, a genetic disorder that causes extreme elevations in cholesterol leading to an increased risk of early cardiovascular disease.
There is no comparable study on the Indian population though there is a fairly high incidence of dyslipidemia. Phase I of the Indian Council of Medical Research–India Diabetes (ICMR-INDIAB) study found 13.9% had hypercholesterolemia, 29.5% had hypertriglyceridemia, 72.3% had low HDL-C, 11.8% had high LDL-C levels and 79% had abnormalities in one of the lipid parameters.
The discrepancy between cholesterol screening and medical treatment was most pronounced in younger patients, uninsured patients and patients without a regular source of healthcare
The US study found frequency of cholesterol screening and awareness were high (at more than 80 percent) among adults with definite/probable familial hypercholesterolemia and severely elevated cholesterol; however, use of cholesterol-lowering statins was low (38 percent). Of those, only 30 percent of patients with severely elevated cholesterol had been prescribed a high intensity statin.
The discrepancy between cholesterol screening and medical treatment was most pronounced in younger patients, uninsured patients and patients without a regular source of healthcare – such as a doctor’s office or an outpatient clinic.
“Young adults may be less likely to think that they are at risk of cardiovascular disease, and clinicians may be less likely to initiate statin therapy in this population. It is possible that lifestyle modifications continue to be prescribed as an initial treatment prior to initiating statin therapy,” wrote lead author Emily Bucholz of Department of Medicine at Boston Children’s Hospital in Massachusetts.
Both the original 2002 National Cholesterol Education Program’s Adult Treatment Panel III (ATP-III guidelines) and the current American College of Cardiology and American Heart Association cholesterol guidelines recommend initiation of statin therapy in patients with LDL cholesterol at or above 190 mg/dL.
“Markedly elevated levels of ‘bad’ cholesterol put you at increased risk of developing heart disease and developing it earlier in life,” said Circulation Editor-in-Chief, Joseph A. Hill. “If your ‘bad’ cholesterol is over 190 you should work with your physician regarding optimal drug treatment, in addition to lifestyle changes and management of other risk factors.”
Study authors said additional studies are needed to better understand how to close these gaps of screening and treatment.
