Study finds that when people use a single pharmacy they stop using crucial heart medicines when it closes
New research from the University of Illinois at Chicago shows that when pharmacies close, people stop taking heart medications. These include statins, beta-blockers and oral anticoagulants that have known cardiovascular and survival benefits.
The researchers, led by UIC’s Dima Qato, report that declines in adherence — including the complete discontinuation of medication — were highest among people using independent pharmacies, filling all their prescriptions at a single store, or living in low-access neighborhoods with fewer pharmacies.
The findings are published in JAMA Network Open.
Among those least likely to experience a decline in adherence were people who regularly used multiple retail stores.
“Although ongoing efforts to improve medication adherence focus on improving affordability, this study suggests that policies aimed at reducing non-adherence to prescription medications should also address system-level barriers beyond the high cost of prescription drugs, like pharmacy access,” said Qato, associate professor of pharmacy systems, outcomes and policy at the UIC College of Pharmacy. “These findings provide strong evidence that pharmacy closures contribute to non-adherence, including among insured older adults.”
Using information from a national all-payer pharmacy dispensing database that links patients across retail and non-retail channels, the researchers analyzed data collected from more than 3 million adults 50 years and older who filled at least one statin prescription at a retail pharmacy between 2011 and 2016. They compared medication adherence among people who had filled a prescription at a pharmacy that later closed — about 93,000 people — with adherence among people whose pharmacy remained open.
The researchers found that statin users in the closure cohort experienced “an immediate and significant decline in statin adherence” in the three months post-closure that was “largely due to the complete discontinuation of medication.”
Among statin users, about 23.8% of people in the pharmacy closure cohort did not refill their prescription at any point during the 12-month follow-up period, compared with only 12.8% in the non-closure cohort.
A decline in adherence also was observed among people who had been adherent to their prescription medications the year prior to the closure. Among those who were fully adherent at baseline, 15.3% in the closure cohort discontinued their statins, compared with only 3.5% in the non-closure cohort.
Qato and her colleagues observed similar trends for beta-blockers and anticoagulants.
Among those least likely to experience a decline in adherence were people who regularly used multiple retail stores.
