Scientists have developed an adhesive patch that can measure blood sugar levels through the skin without the need for the painful drawing of blood
Diabetics can now do away with the mandatory, painful needle prick to keep a tab on their blood sugar levels
Scientists have created a non-invasive, adhesive patch, which promises the measurement of glucose levels through the skin. The patch does not pierce the skin, instead it draws glucose out from fluid between cells across hair follicles, which are individually accessed via an array of miniature sensors using a small electric current. The glucose collects in tiny reservoirs and is measured. Readings can be taken every 10 to 15 minutes over several hours.
Crucially, because of the design of the array of sensors and reservoirs, the patch does not require calibration with a blood sample — meaning that finger prick blood tests are unnecessary.
India has the dubious distinction of being the country with the second largest number of diabetics – 70 million – against the 100 million diabetics in world “leader” China
Having established proof of the concept behind the device in a study published in Nature Nanotechnology, the research team from the University of Bath hopes that it can eventually become a low-cost, wearable sensor that sends regular, clinically relevant glucose measurements to the wearer’s phone or smartwatch wirelessly, alerting them when they may need to take action.
India has the dubious distinction of being the country with the second largest number of diabetics – 70 million – against the 100 million diabetics in world “leader” China. An effective, non-invasive way of monitoring blood glucose could both help diabetics, as well as those at risk of developing diabetes, make the right choices to either manage the disease well or reduce their risk of developing the condition.
The project is a multidisciplinary collaboration between scientists from the Departments of Physics, Pharmacy & Pharmacology, and Chemistry at the University of Bath.
Professor Richard Guy, from the Department of Pharmacy & Pharmacology, said: “A non-invasive – that is, needle-less – method to monitor blood sugar has proven a difficult goal to attain. The closest that has been achieved has required either at least a single-point calibration with a classic ‘finger-stick’, or the implantation of a pre-calibrated sensor via a single needle insertion. The monitor developed at Bath promises a truly calibration-free approach, an essential contribution in the fight to combat the ever-increasing global incidence of diabetes.”
Dr Adelina Ilie, from the Department of Physics, said: “The specific architecture of our array permits calibration-free operation, and it has the further benefit of allowing realisation with a variety of materials in combination. We utilised graphene as one of the components as it brings important advantages: specifically, it is strong, conductive, flexible, and potentially low-cost and environmentally friendly. In addition, our design can be implemented using high-throughput fabrication techniques like screen printing, which we hope will ultimately support a disposable, widely affordable device.”
In this study the team tested the patch on both pig skin, where they showed it could accurately track glucose levels across the range seen in diabetic human patients, and on healthy human volunteers, where again the patch was able to track blood sugar variations throughout the day.
The next steps include further refinement of the design of the patch to optimise the number of sensors in the array, to demonstrate full functionality over a 24-hour wear period, and to undertake a number of key clinical trials.
