Heart disease in your genes? Go, sweat it out

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young woman stretching before exercise
young woman stretching before exercise

Study shows greater grip strength, more physical activity and better cardiorespiratory fitness associated with reduced risk for heart attacks, stroke

If heart disease runs in your family, exercise may be your best bet.

This is the conclusion of a study published in the American Heart Association’s journal, Circulation that assessed data from roughly a half-million people in the UK Biobank database. The study showed that greater grip strength, more physical activity and better cardiorespiratory fitness are all associated with reduced risk for heart attacks and stroke, even among people with a genetic predisposition for heart disease.

 at high genetic risk for cardiovascular diseases, high levels of cardiorespiratory fitness were associated with a 49 percent lower risk for coronary heart disease and a 60 percent lower risk for atrial fibrillation compared to study participants with low cardiorespiratory fitness

For participants with an intermediate genetic risk for cardiovascular diseases, those with the strongest grips were 36 percent less likely to develop coronary heart disease and had a 46 percent reduction in their risk for atrial fibrillation compared to study participants with the same genetic risk who had the weakest grips.

Among individuals deemed at high genetic risk for cardiovascular diseases, high levels of cardiorespiratory fitness were associated with a 49 percent lower risk for coronary heart disease and a 60 percent lower risk for atrial fibrillation compared to study participants with low cardiorespiratory fitness.

For India the findings are significant not just because of the high burden of cardiovascular disease (CVD) but also because exercise is not somethings Indians take to very easily. An update on the CVD incidence of India published in the same journal in 2016, said: “The Global Burden of Disease study estimate of age-standardized CVD death rate of 272 per 100 000 population in India is higher than the global average of 235 per 100 000 population. Some aspects of the CVD epidemic in India are particular causes of concern, including its accelerated buildup, the early age of disease onset in the population, and the high case fatality rate. In India, the epidemiological transition from predominantly infectious disease conditions to noncommunicable diseases has occurred over a rather brief period of time. Premature mortality in terms of years of life lost because of CVD in India increased by 59%, from 23.2 million (1990) to 37 million (2010).”

“The main message of this study is that being physically active is associated with a lower risk of heart disease, even if you have a high genetic risk,” said Erik Ingelsson, M.D., Ph.D., lead author of the study and a professor of Medicine at Stanford University School of Medicine in California.

There are a few caveats: the study is not a prescription for a specific type or amount of exercise and because the results come from an observational study, Ingelsson said, “we can’t definitely claim a causal connection.” Observational studies are designed to establish trends.

Nonetheless, he said the data is robust and these latest results are worthy for consideration in guidelines. For individuals, “it would be best to discuss a physical activity plan with a physician,” Ingelsson said.